Subfamily B ATP Binding Cassette Transporter

A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.

Also Known As:

ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Sub-Family B; ATP-Binding Cassette, Sub-Family B Proteins; ATP Binding Cassette Transporter, Sub Family B; ATP Binding Cassette, Sub Family B Proteins; P Glycoproteins; Multidrug Resistance Proteins; P-Glycoproteins

Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - ATP-Binding Cassette Transporters: 2845
        Subfamily B ATP Binding Cassette Transporter: 258
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - ATP-Binding Cassette Transporters: 2845
        Subfamily B ATP Binding Cassette Transporter: 258
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - ATP-Binding Cassette Transporters: 2845
        Subfamily B ATP Binding Cassette Transporter: 258
      - Ion Pumps: 61
        Anion Transport Proteins: 2
        Organic Anion Transporters: 371
        ATP-Dependent Organic Anion Transporters
        Subfamily B ATP Binding Cassette Transporter: 258
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - ATP-Binding Cassette Transporters: 2845
        Subfamily B ATP Binding Cassette Transporter: 258
    - Membrane Transport Proteins: 589
      - ATP-Binding Cassette Transporters: 2845
        Subfamily B ATP Binding Cassette Transporter: 258
      - Ion Pumps: 61
        Anion Transport Proteins: 2
        Organic Anion Transporters: 371
        ATP-Dependent Organic Anion Transporters
        Subfamily B ATP Binding Cassette Transporter: 258

Sinem Yalcintepe Atik Selected Research

Sinem Yalcintepe Atik Research Topics

Disease

Drug/Important Bio-Agent (IBA)